Computational Protein-Protein Interactions by Ruth Nussinov (English) Paperback

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Computational Protein-Protein Interactions by Ruth Nussinov, Gideon Schreiber

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design. Explores Computational Approaches to Understanding Protein-Protein InteractionsOutlining fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for the prediction of function. The text provides general chapters that overview the topic and also includes advanced material. The chapters detail the complexity of protein interaction studies and discuss potential caveats. Addresses the Next Big Problem in Molecular BiologyWhile it is important to predict protein associations, this is a daunting task. Edited by two experts in the field and containing contributions from those at the forefront of research, the book provides a basic outline of major directions in computational protein-protein interactions research at the heart of functional genomics and crucial for drug discovery. It addresses the next big problem in molecular biology: how to create links between all the pieces of the cell jigsaw puzzle.

FORMAT
Paperback LANGUAGE
English CONDITION
Brand New Table of Contents

Computational design of protein-protein interactions. Molecular Mimicry and Competitive Recruitment. Intrinsically unstructured proteins. The molecular architecture of protein-protein binding sites. Characteristic of protein-protein recognition. Protein-Protein Docking. Identification of hot spots within druggable binding regions. Hot-spot mimicry of ac cytokine receptor. Chaperone-related immune dysfunction. Recognition proteins of the innate immune system. Epitope mapping using combinatorial phage-display libraries. Identification of conserved protein complexes based on a model of protein network evolution. Interaction sites identified from sequences. Thermophilic Protein Complex Stabilized by Topological Interlinked. Protein interface recognition for structural proteomics. Strategies to search and design stabilizers of protein-protein interactions. Dynamics and allostery in protein-protein interactions.

Details ISBN1138113352 Year 2017 ISBN-10 1138113352 ISBN-13 9781138113350 Format Paperback Pages 344 Place of Publication London Country of Publication United Kingdom Edited by Gideon Schreiber Affiliation National Cancer Institute, Frederick, Maryland, USA Publisher Taylor & Francis Ltd Publication Date 2017-05-22 DEWEY 572.64 Language English UK Release Date 2017-05-22 AU Release Date 2017-05-22 NZ Release Date 2017-05-22 Imprint CRC Press Author Gideon Schreiber Illustrations 10 Tables, black and white; 74 Illustrations, black and white Alternative 9781420070057 Audience Professional & Vocational Country of Origin GB Product Class Description Chemistry
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